What is a common symptom of diabetic ketoacidosis?

Diabetic ketoacidosis (DKA) is characterized by a triad of symptoms: hyperglycemia, acidosis, and ketonemia. One of the common mechanisms leading to fatigue in DKA is osmotic diuresis, which occurs when elevated blood glucose levels cause excessive glucose to spill into the urine. This process draws more water into the urine, leading to increased urination (polyuria). As the body loses significant amounts of water and electrolytes, individuals can experience dehydration, which contributes to overall fatigue and weakness.

This mechanism underscores the importance of understanding how hyperglycemia impacts fluid balance and energy levels. Unlike other symptoms that might be linked to different pathophysiological processes, such as metabolic alkalosis or fluid retention, fatigue stemming from osmotic diuresis reflects the direct physiological consequences of poorly controlled diabetes and the resulting metabolic state triggered by DKA.