Which childhood cancer is associated with tumor suppressor genes?

Wilms tumor, also known as nephroblastoma, is indeed associated with tumor suppressor genes, particularly the Wilms tumor 1 (WT1) gene. This cancer primarily occurs in children and is characterized by the development of a mass in the kidney. Abnormalities in the WT1 gene have been identified in many cases of Wilms tumor, and these abnormalities can disrupt normal cell growth and development, leading to tumor formation.

The significance of tumor suppressor genes lies in their role in regulating cell division and preventing tumor growth. When these genes are mutated or dysfunctional, as seen in Wilms tumor, the checks on cell proliferation can be lost, resulting in unchecked growth and cancer progression.

Other options mentioned, while they may involve oncogenes or other genetic factors, do not have the same established link to tumor suppressor genes in the context of pediatric cancers as Wilms tumor does. For instance, acute leukemia is associated more with genetic mutations and chromosomal abnormalities rather than a specific tumor suppressor gene. Cerebellar hemangioblastoma is generally linked to von Hippel-Lindau syndrome, which involves tumor suppression but in a different context, while testicular tumors primarily relate to germ cell tumor pathways rather than direct tumor suppressor