Which condition is most likely in a patient with fatigue, diastolic hypertension, and weight gain?

The presence of fatigue, diastolic hypertension, and weight gain strongly suggests hypothyroidism. In this condition, the underproduction of thyroid hormones leads to a slowed metabolism, which results in weight gain and lethargy. Patients often report fatigue as a common symptom because their bodies are not able to efficiently utilize energy due to the insufficient thyroid hormones.

Diastolic hypertension can occur in hypothyroid patients, as the thyroid hormones play a role in regulating vascular tone and cardiac function. The reduced cardiac output associated with hypothyroidism can lead to increased resistance in the blood vessels, contributing to an elevation in diastolic blood pressure.

In addition to these symptoms, other common manifestations of hypothyroidism include cold intolerance, dry skin, hair loss, and menstrual irregularities, further supporting the diagnosis when fatigue and weight gain are present.

While hyperthyroidism typically presents with weight loss, increased metabolic activity, and symptoms like anxiety and heat intolerance, it doesn’t align with the symptoms described. Similarly, diabetes mellitus may lead to fatigue and weight gain in some cases, but it usually also presents with increased thirst and urination, and the hypertension seen in diabetes is more often systolic rather than diastolic. Thyroid storm is an acute,